5 jobs found in bothell

ROLE SUMMARY The Chemical Process and Analytical Development (CPAD) group located in Bothell, WA is responsible for the development of chemical processes and analytical methods for novel drug-linkers (linker-payloads) used in antibody-drug conjugates (ADCs). Our process chemists, analytical chemists, and chemical engineers collaborate to discover phase-appropriate synthetic routes and chemical processes to accelerate the delivery of life saving medicines to patients, and to develop robust and innovative synthetic processes to novel commercial drug-linker candidates that drive the next generation of targeted cancer therapy. As a Principal Scientist in CPAD, you will provide technical leadership to a team of process chemists engaged in route screening/selection, process development, and process characterization for our growing drug-linker portfolio.  You will drive the development of safe and scalable chemistry by leveraging state-of-the-art technologies such as...

ROLE SUMMARY This scientific leadership role sits within Pfizer’s Biotherapeutics Pharmaceutical Sciences organization and is part of the Pharmaceutical Research & Development (PhRD) department. As Principal Scientist, you will lead formulation development and physio-chemical characterization efforts for Pfizer’s biotherapeutics portfolio (preclinical, clinical, commercial), which includes antibody-drug conjugates (ADCs), monoclonal antibodies, and proteins.   Success in this role demands exceptional time management, strong communication skills, meticulous attention to detail, and the ability to work in a cross-functional environment. A broad understanding of formulation design principles, analytical methodologies, biophysical characterization techniques, and process development is essential. The ideal candidate will contribute to regulatory documentation by generating source materials for formulation selection and characterization. ROLE RESPONSIBILITIES...

POSITION SUMMARY  As a Scientist on our Antibody-Drug Conjugate (ADC) Biology team, you will play a pivotal role in driving the development of next-generation ADCs for cancer therapy. Through collaborative, cross-functional research spanning early discovery to clinical development, you will help shape innovative therapeutic strategies that address unmet medical needs. In this role, you will design and implement robust biological assays and screening strategies to evaluate novel payload chemotypes and uncover their mechanisms of action. You will help identify cancer indications most susceptible to these payloads and optimize their pairing with tumor-associated antigens to enhance therapeutic efficacy. You will analyze, interpret, and clearly communicate experimental data to multidisciplinary teams and key stakeholders. You may contribute to the generation of IND- and BLA-enabling data packages, supporting regulatory submissions and clinical advancement. You may integrate...

POSITION SUMMARY  As a Scientist on our Antibody-Drug Conjugate (ADC) Biology team, you will play a pivotal role in driving the development of next-generation ADCs for cancer therapy. Through collaborative, cross-functional research spanning early discovery to clinical development, you will help shape innovative therapeutic strategies that address unmet medical needs. In this role, you will design and implement robust biological assays and screening strategies to evaluate novel payload chemotypes and uncover their mechanisms of action. You will help identify cancer indications most susceptible to these payloads and optimize their pairing with tumor-associated antigens to enhance therapeutic efficacy. You will analyze, interpret, and clearly communicate experimental data to multidisciplinary teams and key stakeholders. You may contribute to the generation of IND- and BLA-enabling data packages, supporting regulatory submissions and clinical advancement. You may integrate...

ROLE SUMMARY This scientific leadership role sits within Pfizer’s Biotherapeutics Pharmaceutical Sciences organization and is part of the Pharmaceutical Research & Development (PhRD) department. As Principal Scientist, you will lead formulation development and physio-chemical characterization efforts for Pfizer’s biotherapeutics portfolio (preclinical, clinical, commercial), which includes antibody-drug conjugates (ADCs), monoclonal antibodies, and proteins.   Success in this role demands exceptional time management, strong communication skills, meticulous attention to detail, and the ability to work in a cross-functional environment. A broad understanding of formulation design principles, analytical methodologies, biophysical characterization techniques, and process development is essential. The ideal candidate will contribute to regulatory documentation by generating source materials for formulation selection and characterization. ROLE RESPONSIBILITIES...